Search for: [Abstract = "Background\: Adiponectin, a protein secreted by adipose tissue but present at low levels in obesity, is now widely recognized as a key determinant of insulin sensitivity and of protection against obesity\-associated metabolic syndrome. The adiponectin gene is very polymorphic and several of its variants contribute to adiponectin level, function and are associated with metabolic syndrome phenotypes. The results differ ethnically. Aim\: To investigate associations of three single nucleotide polymorphisms \(SNPs\) 45T>G, 276G>T, \-11391G>A of the adiponectin gene and metabolic syndrome phenotypes in the population of South of Poland. Methods\: 100 non\-diabetic subjects were selected according to the ATP III definition. To estimate the link between type 2 diabetes \(DM2\), 550 DM2 patients and 494 controls were included. The anthropometric measurements \(weight, height, waist and hip circumference\) and level of biochemical parameters including fasting adiponectin, leptin, insulin, glucose, cholesterol, triglyceride, free fatty acids and von Willebrand factor were assessed. Two types of Oral Lipid Tolerance Tests \(OLTT\) were included. The SNPs of the adiponectin gene were determined by PCR\-based assay for the analysis of restriction fragment length polymorphism. New indices of insulin resistance such as leptin\/adiponectin ratio \(L\/A\), HOMA\-AD were calculated. Statistical analyses were perform"]

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