Search for: [Abstract = "BACKGROUND\: Among patients referred to cathlab with the diagnosis of ACS exists a subgroup presenting with symptoms of myocardial ischemia and no critical lesions in coronary angiography. OBJECTIVES\: We investigated the value of reactive hyperemia peripheral arterial tonometry \(PAT\) as a noninvasive tool for identification and stratification of clinical outcome in patients with ACS and no significant coronary lesions \(non\-obstructive CAD\), as well as its changes in response to high and low dose statin therapy. METHODS\: Between September 2009 and October 2011 fifty patients with diagnosis of acute coronary syndrome \(STEMI, NSTEMI\) with coronary angiography considered as normal or near\-normal were included. Patients were randomized to two groups\: receiving atorvastatin 20 mg OD \(group A\) or atorvastatin 80 mg OD \(group B\). PAT examinations were performed at screening, 1 month and 3 months follow–up visits. During 12 months clinical follow\-up incidence of major adverse cardiac events was assessed. RESULTS\: During the follow\-up there was a trend for better outcome \(MACE rate\) in group B \(12%\) than in group A \(28%, p=0,09\). Average RHI was significantly higher after one and three months in group B than in group A. On multivariate analysis\: atorvastatin 80 mg administration, smoking, ST\-segment elevation on admission ECG were independent positive predictors of restoration of correct"]

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