Search for: [Abstract = "Article no 5 published in Pancreatology 2015\; 15\: 344\-351 describes concentrations of selected microRNA, that in the literature are5associated with pancreatic, hepatic and endothelial damage, in patients in early phase of AP. Especially, associations are reported between serum concentrations of microRNAs of endothelial origin \(hsa\-miR\-126\-5p and has\-miR\-551b\-5p\) and severity of AP.Presented PhD thesis aimed at evaluating the diagnostic and prognostic usefulness of angiopoetin\-2 and NGAL as markers of the severity and complications of AP in the early phase of the disease \(first 72 hours\). Despite intense studies on the patomechanism of AP and searching for optimal markers of severity of the disease, obtained results are original and unique depiction of the problem. Studies on the concentration of Ang\-2 and microRNA in the serum of patients in the early phase of AP were carried out for the first time in Polish population and delivered new information on the scope and dynamics of changes of concentrations of these markers in course of AP of various severity. The observations regarding sNGAL and uNGAL confirmed the findings of another authors. However, the evaluation of diagnostic usefulness of these markers enables their better use in clinical practice. It is concerned especially to uNGAL as routine laboratory test.The presented results provide a supplement to clinical data regarding the diagnostic tools that may be used at the early stage of qualification patients with AP to the most appropriate group of disease severity. In the future, it might be helpful in creation of certain treatment strategy, dictated by significantly worse prognoses in patients with SAP. However, obtained results should be confirmed by studies carried out on a larger groups of patients."]

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