Search for: [Abstract = "Antidepressant drugs\/compounds induced several changes in the endocannabinoids levels, in most cases these changes were related to expression of their metabolizing enzymes. After acute administration of drugs\/compounds \(IMI or NAC\) it was observed an increase of anandamide in the hippocampus and dorsal striatum, and altered levels of 2\-AG were seen in the prefrontal cortex after NAC treatment, frontal cortex after ESC and IMI treatment \(with increased DAGLα expression\), dorsal striatum after URB597 treatment or cerebellum after IMI or NAC treatment. The chronic administration of all investigated drugs\/compounds increased anandamide levels in the hippocampus and dorsal striatum, as well as an increase of anandamide levels in the frontal cortex after NAC treatment and cerebellum after URB597 treatment was noted. Raised levels of anandamide were associated with increased NAPE\-PLD expression in the frontal cortex, hippocampus and dorsal striatum \(after NAC or ESC treatment\), or reduced FAAH expression in the hippocampus and dorsal striatum \( after URB597 or IMI, ESC, NAC administration, respectively\). The 2\-AG levels were increased in the frontal cortex \(IMI, TIA, NAC\), hippocampus \(ESC\) and dorsal striatum \(all drugs\/compounds\) or decreased in the prefrontal cortex \(ESC, NAC\), frontal cortex \(ESC\), nucleus accumbens \(NAC\) and cerebellum \(IMI, ESC, NAC\). These changes were resulted from altered expression of 2\-AG metabolizing enzymes\- expression of 2\-AG synthesizing enzyme \(DAGLα\) or expression of degrading enzyme \(MAGL\). Antidepressant drugs\/compounds altered density and expression of CB receptors. An increase of CB1 receptors density was seen in the cortical structures after chronic administration of ESC, TIA or URB597 and in the hippocampal areas after IMI, ESC, TIA and NAC administration, while a decrease of CB1 receptors density in the dorsal striatum after IMI and ESC administration and in the nucleus accumbens after chronic IMI treatment was reported. These changes were confirmed in the study on expression of CB1 receptors. Additionally, for the first time changes in expression of CB2 receptors after antidepressant drugs\/compounds were reported, an increase of expression of CB2 receptors was observed in the cortical structures and hippocampus after administration of ESC, TIA or NAC, as well as a decrease of this expression was noted in the dorsal striatum, nucleus accumbens and cerebellum after IMI administration. The effects of antidepressant drugs\/compounds on the endocannabinoid system seem to be short\-lived, endocannabinoids levels returned to control \(vehicle\) levels after a 10\-day washout period of IMI, TIA, NAC and URB597. Raised levels of these neurotransmitters were maintained in the hippocampus and dorsal striatum even after a 10\-day washout period of ESC.Specificity of effects occurring after antidepressant drugs\/compounds were related to activity of CB1 and CB2 receptors. Only the mechanism of changes in the levels of 2\-AG in the dorsal striatum after ESC treatment was not related to CB1 receptors, while changes in the levels of this neurotransmitter in the frontal cortex and hippocampus \(after administration of IMI, TIA or ESC, respectively\), and changes in the levels of anandamide in the dorsal striatum and frontal cortex \(after administration of IMI, ESC, TIA or NAC, respectively\) were not dependent on the receptor CB2."]

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