Search for: [Abstract = "Amyotrophic lateral sclerosis \(ALS\) is a progressive, incurable, multiple system neurodegenerative disease affecting upper and lower motor neurones. This PhD dissertation presents an evaluation of conduction parameters in peripheral neurones, electromyographic characteristics, as well as mood and cognitive function disorders accompanying the progression of limb impairment in ALS patients. Twenty subjects were enrolled in the study, assigned to two groups, with clinically confirmed or suspected ALS diagnosis, without comorbidities that could affect limb function. The studies showed that the compound muscle action potential \(CMAP\) and the minimal F wave latency are the most useful electroneurographic parameters for early diagnosis and disease monitoring, while the duration of individual motor unit potentials \(MUP\) is the most useful of electromyographic parameters. A gradual reduction in CMAP amplitude was found, accompanied by the prolonged minimal F wave latency and MUP duration. The progression of limb impairment was a clinical manifestation of these disorders, and this was confirmed by increasingly poorer clinical test results. The limb impairment was accompanied by cognitive impairment, with a tendency to progression over time. The depressive disorders were transiently deteriorated. The patients with limb\-onset ALS had poorer motor conduction parameters and poorer limb fun"]
