Search for: [Abstract = "Adipose tissue secrets a large variety of highly active proteins like leptin and resistin, regulating metabolism, appetite, as well as modulating inflammatory process. These adipose – derived proteins are thought to contribute to the pathogenesis of endothelial dysfunction, atherosclerosis, hypertension, and insuline resistance. Oxidative stress and overproduction of reactive oxygen species \(ROS\) is a key factor in the pathogenesis of endothelial dysfunction. NADPH oxidase are the main source of superoxide in the veins and arteries of individuals with atherosclerosis risk factors. Because oxidative stress and increased superoxide production by NADPH oxidase are critical in pathogenesis of endothelial dysfunction, we aimed to study the effects of leptin and resistin on vascular superoxide production, NADPH oxidase activity and endothelial function. We also studied the vascular effects of ghrelin, a novel peptide hormone which biological effects appear to be opposite to those of leptin. Ghrelin was shown to decrease blood pressure and improve endothelial function. Superoxide production and NADPH oxidase activity were determined by lucigenin\-enhanced chemiluminescence \(5 μM\) from intact human vessel rings \(internal mammary arteries – IMA and saphenous veins \- SV\) from patients undergoing coronary artery bypass graft surgery and from animals thoracic aorta \(rats \- WKY, SHR\: mice \-"]

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