Search for: [Abstract = "Adipose tissue is a highly active endocrine organ secreting a range of compounds with both local and distant actions. Adiponectin is one of the endogenous adipose\-derived factors, named adipokines, which has been demonstrated to play an important role in the modulation of the liver glucose and lipid metabolism. Recently two types of adiponectin receptors have been found. In the contrary to leptin, the decreased plasma level of Adq is observed in patients with obesity and type 2 diabetes. Adiponectin exerts many anti\-inflammatory and anti – atherogenic properties. Modulation of the adiponectin level in plasma by nutrients \(fatty acids, glucose\) and insulin\-sensitizing drugs \(PPAR agonists ie glitazones\) may support the normal blood\/vessel wall homeostasis. The stromal vascular fraction \- SVF play an essential role in the adipose tissue mass since it consist of the adipocyte and endothelial progenitor cell fraction. In this project the influence of FFA and some PPAR agonists on expression of adiponectin and its receptors in the adipose tissue derived SVF was investigated. Isolation and culture of human stromal adipose tissue progenitor cells was done using modified Hauner method. After checking the cytotoxicity of examinated substances, the influence of FFA and PPAR agonists on proliferation, migration, tube formation as well as differentiation to adipocytes of investigated cells"]
