Search for: [Abstract = "Acute lymphoblastic leukemia \(ALL\) is the common form of pediatric cancer. It has been suggested that polymorphic variations of some metabolically important genes, together with environmental factors, could contribute to the leukaemia development. Presented study has been performed for the purpose of evaluating the role of carcinogen\-metabolizing enzymes and folate pathway enzyme genetic polymorphisms in susceptibility to childhood ALL in Polish population. Further aim of the study has been the description of the frequency of selected polymorphisms in Polish healthy children population. The study group included 1000 healthy newborns, selected from the total of Polish population. The results of analogous 3 genotyping for 400 children with ALL recruited by Polish regional oncology centers have been used as well. Results of the present study suggest that neither the presence of GSTT1\*0\/\*0 nor GSTM1\*0\/\*0 genotype of glutathione S\-transferase gene has been associated with increased risk of childhood ALL in Polish population. Further results of combined genotype analysis of these two polymorphisms reveal no association with ALL. In the next phase, the effect of GSTP1\*B\(313A>G\) genetic polymorphism of glutathione Stransferase Pi1 gene has been investigated. Observed frequency of GSTP1\*B allele has been higher in the cases relative to the controls \(p=0,0006\;OR=1,54\). The prevalence of"]

Number of results: 1