Search for: [Abstract = "According to World Health Organization forecast, in this century cancers will become the most common cause of death in most of countries, affecting more people than cardiovascular diseases. Effective cancer pharmacotherapy is still one of the most challenging for modern medicine and pharmacy. Despite development and introduction of plenty of innovative anticancer drugs, substances that have been using for many years are still widely used in therapy. Anthracycline antibiotics \(ANT\) are one of such groups of drugs. They are using in treatment of both solid tumours and haematological malignancies. Unfortunately, their usage is limited due to drug resistance developing during the therapy and increased risk of cardiotoxicity. The reasons behind those effects are still unclear. One of the hypotheses suggests that they are caused by ANT metabolites formed by enzymes called reductases. The main enzymes responsible for this process are carbonyl reductase 1 \(CBR1\) and aldo\-keto reductase 1C3 \(AKR1C3\). Thus, inhibition of those enzymes should increase drugs activity and limit their cardiotoxicity. The aim of the research presented in this thesis was application of selected computer\-aided drug design methods in optimization of selected CBR1 and AKR1C3 three\-dimensional crystal structures and then to use the optimized models in searching for new enzymatic inhibito"]

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