Search for: [Abstract = "Abnormal fibrin clot structure and hypofibrynolysis may be important in several diseases including advanced coronary artery disease. It is not known if decreased permeability and resistance for lysis of the clots can also be found in patients with peripheral artery occlusive disease \(PAOD\) and with inflammatory artery diseases like Buerger disease either. The aim of the study was to evaluate fibrin clot properties, such as permeability and susceptibility to fibrinolysis, and identify factors which influence these variables in patients with peripheral atherosclerotic occlusive disease and Buerger disease. 55 consecutive patients with PAOD aged 44 to 70 and 16 patients with Buerger disease aged 38 to 56 years were enrolled to the study. Control groups consisted of 30 and 17 healthy age\-matched volunteers, respectively. In both patient groups \(PAOD and Buerger\) the grade of the lower extremity ischaemia was assessed. In all patients, blood samples were drawn for the measurement of lipids, concentration of fibrinogen, C\-reactive protein, interleukin\-6, intercellular adhesion molecule\-1 \(ICAM\-1\), plasma and cellular fibronectin, fibrinopeptide A, tissue plasminogen activator antigen and plasminogen activator inhibitor\-1 antigen. Fibrin clots obtained from citrate plasma samples were used for the measurement of clot permeation, expressed by the permeability coefficient, Ks \(Darcy con"]

Number of results: 1