Search for: [Abstract = "A statistical positive correlation between the BMI, HgB, HCT, CRP, fibrinogen, platelet count and albumins level and pathological changes in the oral cavity of the CD patients was observed. No association between the CDAI and pathological changes in oral cavity in CD patients was found. Obtained results show clear interaction of the increased IL\-6 level in the saliva with the oral cavity pathological changes, and this correlation was also true for TNF\-alfa, however not so obvious \(positive Pearson and tau\-Kendall correlations\). No correlation was observed between the saliva production, DMF and oral cavity pathological changes in patients with CD. In summary, a special attention should be paid in clinical examination of the oral cavity in CD patients, while 3\-5% of these adult patients \(and even more according to other authors\) may have pathological findings. These changes may precede the typical GIT manifestation of the disease, and if accurately diagnosed may help in establishing the diagnosis and starting the proper treatment, and therefore to prevent concomitant exacerbations of the disease. In this performed study on CD patients, both in exacerbation and in clinical remission some important clinical outcomes were found, namely\: 1\) the oral cavity pathological changes were found in CD patients, and among them the non specific changes were more common\; 2\) the saliva production did not differ among the CD patients and HC. No differences were neither observed, when the CD patients were divided according to the disease activity\; 3\) the proinflammatory cytokines\: IL\-6 and TNF\-alfa were increase in the CD patients when compared to HC, and IL\-6 level was higher in the active phase of the CD when compared to remission. The IL\-10 level in CD patients both in remission and exacerbation was lower than in HC\; 4\) statistical correlation was observed between the pathological changes in oral cavity in CD patients and\: HgB, HCt, blood platelet count, CRP, fibrinogen, BMI, albumins and icreased levels of IL\-6 and TNF\-alfa in saliva. No correlation was observed between oral cavity pathological changes and DMF, CDAI, saliva production and levels of IL\-1 beta and IL\-10."]

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