Search for: [Abstract = "A role of elevated homocysteine \(Hcy\) levels in autoimmune disorders and their complications remains unclear. One of the recently discovered mechanisms underlying harmful effects of Hcy is the generation of Nε\-homocysteinylated proteins \(Nε\-Hcy\-proteins\) such as Nε\-homocysteinylated\-albumin \(Nε\-Hcyalbumin\) and Nε\-homocysteinylated\-hemoglobin \(Nε\-Hcy\-hemoglobin\), which may stimulate a specific humoral immune system response. Anti\-Nε\-Hcy\-protein IgG antibodies have been detected in subjects with ischemic heart disease, with endstage renal disease and after stroke. The level of anti\-Nε\-Hcy protein antibodies in the patients was significantly higher compared with age\- and sex\-matched controls. It is still not known whether in autoimmunologic diseases, in which increased plasma levels of Hcy are commonly observed, there is a tendency to produce anti\- Nε\-Hcy protein antibodies. The aims of the study were\: 1. to assess the occurrence of anti\-Nε\-Hcy\-albumin and \-hemoglobin antibodies in patients with the most common systemic auotoimmunologic disorders, i.e. systemic lupus erythematosus \(SLE\) and antiphospholipid syndrome \(APS\), 2. to identify factors that determine these antibodies in autoimmunologic diseases, 3. to assess variability of levels of anti\-Nε\- Hcy\-protein antibodies in patients with autoimunologic disorders. One hundred and thirty patients \(108 women, 22"]

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