Search for: [Abstract = "A phenomenon termed aspirin \(ASA\) resistance with a prevalence from 5.5% to 61% of treated subjects is considered to be a potential cause of ASA’s failure in the prevention of atherothrombosis. At present, there is no widely accepted definition of ASA resistance or diagnostic criteria and tests to evaluate this phenomenon. The cause of ASA resistance also remains unclear. Until now ASA resistance has not been investigated in pregnant women taking this drug. The aim of this study was to evaluate the influence of pregnancy on the occurrence of ASA resistance and to determine factors that may increase the risk of this phenomenon, especially antiphospholipid syndrome \(APS\), inflammation, the presence of PlA2 allele. We also sought to investigate the effect of decreased sensitivity to ASA on the pregnancy, delivery, puerperium and newborn state. A case\-control study was performed on 75 pregnant women, aged 20 to 44 years. Forty\-three women took 75 mg of ASA daily. The main cause of ASA intake was APS \(n=27\). The remaining 32 women, who were not treated with ASA, represented 24 healthy women and 8 women with systemic lupus erythematosus \(SLE\). Venous blood and urine samples were obtained 3 times\: between 18 and 22 weeks of gestation \(2nd trimester\), between 28 and 32 weeks of gestation \(3rd trimester\) and after puerperium \(on average 26 weeks after childbirth\). To identify patients r"]
