Search for: [Abstract = "A chromatographic\-densimetric method has been worked out, useful for identification and quantitative determination of eight cephalosporins\: cefotaxime, cefuroxime, 1\-acetoxyethyl ester of cefuroxime, cefadroxil, cefalexin, cefaclor and ceftriaxone. For three of them\: acetoxyethyl ester, cefaclor and ceftriaxone, where the phenomenon of stereoisomerism occurs, validation of the method has been carried out. The method was used in subsequent examinations for determining not only the active substances content but also the content of their hydrolytic decomposition products. Conditions were established for chromatographical separation of rsomers of 1\-acetoxyethyl ester of cefuroxime, cefaclor and ceftriaxone, with the use of a chiral modifier \- B\-cyclodextrine. The content of the individual isomers was determined in standard substances and m pharmaceutical preparations chosen at random from the circulation. The structure and identity of the separated isomers were verified with the 1H NMR and TLC methods in the case of 1\-acetoxyethyl ester of cefuroxime and cefaclor, and with the TLC method in the case of ceftriaxone. Stability of the cephalosporins was examined in acidic solutions without as well as with the presence of P\-cyclodextrine. Determination was carried out m solutions of different acidity, choosing for the later examinations such hydrochloric acid concentration at w"]

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