Search for: [Abstract = "28 % in the controls \(TGA\). Children with HLHS that did not survive showed the peak concentration 6 hours after the surgery, just prior to death, and the Et\-1 value achieved at this measurement proved a significant factor associated with the risk of death. The mean Et\-1 concentration measured 20 hours postoperatively in children with hypoplastic left heart syndrome was still high, while in patients with transposition of the great arteries it reached its lowest value, being lower than preoperatively. Based on the results, the following conclusions were formulated\: 1. In the perioperative period \(the Norwood procedure\), hypoplastic left heart syndrome, as a congenital heart defect of a single ventricle\-type, provides hemodynamic conditions favoring high serum endothelin\-1 concentration values in arterial blood. 2.Endothelin\-1 may contribute to the pathomechanisms leading to circulatory failure in newborns with hypoplastic left heart syndrome in the early postoperative period. 3.The restoration of normal anatomical and hemodynamic conditions as a result of surgical treatment of congenital heart defects decreases serum Et\-1 concentration values in arterial blood. 4.Cardiopulmonary bypass with deep hypothermia and extracorporeal circulation arrest are not decisive factors in generating high serum Et\-1 values in arterial blood of newborns with congenital heart defects. 5.Preoper"]

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