Search for: [Abstract = ".15 \[95%CI\: \- 0.23 to \-0.07\]\). The multiple regression model showed that cFn in asthma is the strongest predictor for endogenous thrombin potential \(ETP\) and for clot lysis time \(CLT\) among the variables assessed in the study. ARTICLE II Plasma Lp\-PLA2 activity in severe asthma was lower than in non\-severe asthma \(203 \[181\-229\] vs. 224 \[191\-261\] nmol\/min\/ml, p=0.006 after adjustment for potential 3 confounders\). In asthma, an inverse relationship was found between plasma Lp\-PLA2 and markers of systemic inflammation, in particular, tumor necrosis factor α \(β= \-0.27 \[95%CI\: \- 0.35 to \-0.20\]\) and hsCRP \(β= \-0.1 \[95%CI\: \-0.19 to \-0.02\]\), and between circulating Lp\-PLA2 and parameters describing plasma thrombin generation profile \(for ETP\: β= \-0.14 \[95%CI\: \-0.21 to \-0.06\]\). ARTICLE III Asthma was characterized by elevated circulating H3cit \(17.49 \[11.25–22.58\] vs. 13.66 \[8.66–18.87\] ng\/ml, p=0.03\). H3cit was increased in asthma patients receiving systemic steroids \(21.07 \[15.9–32.0\] vs. 16.21 \[10.52–20.27\] ng\/ml, p=0.02\). In asthmatics, a positive association between serum H3cit and total lung capacity \(TLC\) was demonstrated \(β= 0.37 \[95%CI 0.24–0.50\]\). CONCLUSIONS\: ARTICLE I For the first time, elevated plasma cFn in asthma and its positive correlation with disease severity, coagulation activation and markers of inflammation have been demonstrated. These new"]

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