Search for: [Abstract = ". The dose of aspirin had an effect on PGD2\-M excretion and there was no correlation between PGD2\-M excretion and maximal intensity of skin eruptions expressed as PASImax. Baseline urinary PGE2\-M concentrations did not differ between groups\: AIU, AIU\+\+, AIU\+\- and healthy controls. After aspirin challenge PGE2\-M concentrations in urine decreased significantly irrespectively of aspirin challenge results. Conclusion\: Aspirin hypersensivity manifests as only skin symptoms in patients with chronic idiopathic urticaria and is characterized by fluctuations. Nevertheless, aspirin hypersensivity is still observed in around 2\/3 patients after four years follow\-up. The persistence of aspirin hypersensivity is determined by the degree of its intensity. Those patients who react lively even after small doses of aspirin have the highest probability of a persistent reaction during four years. The LTE4 concentration in urine after the aspirin challenge is increased almost significantly higher \(p\) than the baseline values in AIU patients. There is correlation between the LTE4 concentration in urine after aspirin challenge and intensity of skin eruptions expressed as PASImax. \; Measurement of PGD2\-M concentration in urine does not differentiate the patient’s response to aspirin. Aspirin decreases systemic PGE2 production in aspirin\-induced urticaria, independent of the result of the aspirin chall"]

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