Search for: [Abstract = ". Additionally a new functional group was introduced, which enhanced affinity to DA, NE, 5\-HT transporters. A set of seventeen compounds based on N\-benzylamide analogues of GABA and GHB was obtained with reasonably high in vitro activity for NET, SERT and DAT. Among the factors affecting selectivity and activity, one can enlist the substituents in N\-benzylamide aromatic ring. It should be also noted that simplification in ligand structure affects observed in vitro affinities. The results of recently conducted in vivo examinations, concerning analgesic properties, confirm potential activity of one of the obtained selective DAT inhibitors after systemic administration. To summarize, the obtained preliminary results are a good starting point for an advanced investigation toward selective DAT, NET and SERT inhibitors. In the course of conducted research, important structural factors present in the synthetized ligands were identified. Novel promising lead structures were proposed among N\-benzylamide derivatives of 4\-aminobutanoic acid or 4\-hydroxybutanoic acid prove to be promising hits."]

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