Search for: [Abstract = "with lower disease activity \(BASDAI 1.74\(\(0.4\)\) and ASDAS 1.1 \(\(0.25\)\), p=0.001 respectively\). However, no differences were detected in the comparison of subgroups of axSpA \(AS and nr\-axSpA\). Conclusions This study found that young patients with RA and axSpA without classical cardiovascular risk factors with moderate disease activity have largely preserved macro\- and microvascular endothelial function compared to healthy controls. Disease activity, duration of the disease, mode of therapy, presence of RA\-specific antibodies or subtype of axSpA \(AS or nr\-axSpA\) where not related to endothelial function. However, in a subset of patients with higher TC and LDL, but still within the range that would not require pharmacological intervention, endothelial dysfunction was detected in the conduit artery, suggesting a permissive role of subclinical lipid disturbances in the development of endothelial dysfunction. Furthermore, in the subset of patients with elevated CRP and ESR, higher parameters of FMD \[%\] and shear rate were detected, suggesting an early endothelial compensatory response to systemic inflammation in young patients with RA and axSpA. However, neither effect was related to disease activity. In a subset of patients with axSpA, microvascular endothelial dysfunction was also detected in FMFS and again could not be related to the increased disease activity expressed as BA"]
