Szukana fraza: [Abstrakt = "ting diverse activity profiles across the used cell models. As part of the research, the synthesis and physicochemical characteristics of new vanadium\(V\) complexes of the ONS type with thioanilide derivatives of amino acids were described for the first time. These complexes were subjected to extensive pharmacological activity studies. The complexes exhibited inhibition of human protein tyrosine phosphatases \(PTP1B, LAR, SHP1, and SHP2\) in the submicromolar range, as well as inhibition of non\-tyrosine phosphatases \(CDC25A and PPA2\), similar to the BMOV complex. The ONS\-type complexes increased the transport of radiolabeled \[14C\]\-deoxy\-D\-glucose into C2C12 myocytes. Specifically, VC070, one of the ONS complexes, also enhanced this transport in 3T3\-L1 adipocytes. These complexes inhibited gluconeogenesis in HepG2 hepatocytes, but none of them reduced lipid accumulation in a non\-alcoholic fatty liver disease \(NAFLD\) model in the same cells. Compared to the simultaneously tested newly synthesized vanadium complexes of the ONO type with 5\- bromosalicylaldehyde and substituted benzhydrazides as ligand components of Schiff base type, the ONS complexes exhibited stronger inhibition of protein tyrosine phosphatases. However, the ONO complexes generally showed higher activity in cellular models. Complexes from ONO group inhibited hepatic gluconeogenesis and lipid accumulati"]

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