Search for: [Abstract = "t of interdisciplinary cooperation with the Faculty of Chemistry of the Jagiellonian University in Krakow during the Cross\-institutional PhD Studies ”Interdisciplinarity for Innovation Medicine” InterDokMed. The studies were in line with good medical practice, in accordance with the Helsinki Declaration, approval of the Bioethics Committee of the Jagiellonian University was obtained. Differences in erythrocytes in terms of changes in heme structure and protein enzymes involved in hemoglobin degradation were observed, both between malaria patients and healthy volunteers, as well as between patients infected with different Plasmodium species. The bands of aspartic proteinases, which lead to the lysis of hemoglobin into oligopeptides, and whose origin can be attributed to the activity of parasites, were also indicated. Marker bands indicating lipid disorder\/order in the erythrocyte membrane as an increase in the gauche to trans conformation ratio were determined. In order to better compare changes in the erythrocytes of patients diagnosed with malaria caused by P. falciparum or P. vivax, a statistical method of data processing was used \- principal component analysis \(PCA\) and two\-dimensional correlation \(2D\-COS\). They made it possible to highlight the differences. Therefore, Raman spectroscopy can be used to assess structural changes in erythrocytes depending on the"]

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