Search for: [Abstract = "rise of DAGLα expression and a fall of MAGL expression was noted in the prefrontal cortex, an increase of FAAH expression was observed in the hippocampus or an increase of NAPE\-PLD and MAGL expression in the nucleus accumbens was reported. Additionally, it was observed a decrease of CB1 receptor expression in the hippocampus, dorsal striatum and nucleus accumbens and a decrease of CB2 receptor expression in the prefrontal cortex and hippocampus, while the CB1 receptor density in the autoradiography was disturbed in the prelimbic cortex and dorsal striatum. The common change for both models was weakness of endocannabinoid signalization \(anandamide\) in the dorsal striatum, what can induce characteristic symptom of depression, anhedonia. In other brain structures, neurochemical changes were different and it seem to be associated with the particular brain structure, and the factor inducing depression \(surgical removal of the olfactory bulbs vs. genetic modulation\). \; Antidepressant drugs\/compounds induced several changes in the endocannabinoids levels, in most cases these changes were related to expression of their metabolizing enzymes. After acute administration of drugs\/compounds \(IMI or NAC\) it was observed an increase of anandamide in the hippocampus and dorsal striatum, and altered levels of 2\-AG were seen in the prefrontal cortex after NAC treatment, frontal cortex after ESC"]

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