Search for: [Abstract = "of life, decreasing the frequency of asthma exacerbation episodes and reducing the dose of systemic glucocorticosteroids. In addition, the present authors observed a tendency towards an improvement of the FEV1 value and a decrease in the number of eosinophils in the peripheral blood, while the group of patients subjected to bronchofiberoscopy showed a decreased number of eosinophils in bronchoalveolar lavage fluids and in bronchial mucosa sections, although no statistical significance was noted. Apart from the clinical improvement, the authors also observed a positive effect of omalizumab treatment on airway remodeling in patients with severe allergic asthma resulting in decreased fibronectin accumulation and a decrease in RBM thickness. The decrease in fibronectin deposits was associated with an improvement in asthma control and improved quality of life, as well as a decreased dose of oral glucocorticosteroids. The omalizumab therapy additionally resulted in a decrease in matrix metalloproteinases \(MMP\) concentration values in broncho\-alveolar lavage \(BAL\) samples. A decrease in the MMP concentration values was associated with a decrease in the frequency of disease exacerbation episodes and an improvement in symptoms control. The clinical importance and the effect of decreased MPP concentration levels on asthma severity and airway remodeling requir"]

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