Search for: [Abstract = "multiple serum samples for quantitative HPLC analysis of olanzapine were collected from each patient upon admission and after 6, 12, 18, 24, 30, 36, 42, 48, 60 and 72 h. Toxicokinetic modeling was performed according to population pharmacokinetic rules using NONMEM® version 7 and assuming the linear bicompartmental model for olanzapine. Statistical analysis was carried out with appropriate tools in STATISTICA version 9.0 PL. Results. The most common symptoms of acute olanzapine poisoning in the study group were\: tachycardia \(85%\), psychomotor agitation \(81%\), hypertension \(73%\), miosis \(65%\) and coma with GCS<9 \(54%\). The medium values of toxicokinetic parameters were as follows \(for abbreviations see the beginning of this thesis\)\: D = 352,5 ± 220,0 mg\; Cmax = 624,9 ± 634,4 ng\/mL\; tmax = 11,9 ± 8,1 h\; Vss\/F = 627,9 ± 232,6 L\; Cl\/F = 13,2 ± 10,2 L\/h\; AUC\(0\-∞\) = 39,3 ± 40,5 mg•h\/l\; V1 = 47,6 ± 2,4 L and t½β = 53,1 ± 33,7 h. Statistical analysis revealed the following significant correlations\: between Cmax and BRmin, TCOMA, Thosp\; between AUC\(0\-∞\) and BRmin, TCOMA, Thosp\; between Cl\/F and PUPØ, BILmax and between D and COMAGCS, COMAMat, BRmax, TEMPmax, PUPreac, TCOMA, TINT, Thosp. None of the operands SEX, AGE, BW, ALC, SMK, DEC and OLZ were found to have a significant influence on Cl\/F or Vss\/F, but some of them could wield such influence with p\-value close to 0.05, namely, SMK"]

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