Search for: [Abstract = "in postoperative specimen in compared with the group of patients with FA. No significant differences were identified in prevalence of early postoperative complications among the study group and the control group patients\: unilateral recurrent laryngeal nerve \(RLN\) palsy 3.38% vs. 1.49%\; p= 0,08\), hypocalcemia \(5% vs. 5.4%\; p=0.86\), postoperative hemorrhage \(1.25% vs. 0.44\; p=0.29\). The analysis of complication frequency based on range of surgery revealed the postoperative hemorrhage and RLN palsy occurred in patients after total thyroidectomy. The third study shows the results of molecular analysis – differential expression of miRNA between FA and WDTC. We found that the expression level of two miRNAs, miR\- 146b\-5p \(p=0,031\) and miR\-146b\-3p \(p= 0,034\) were significantly higher, whereas miR\-195\- 3p \(p=0,032\) occurred to be significantly lower in patients with WDTC than in patients with FA. The results have been validated using external TCGA data cohort. Overall Jagiellonian University Medical College signature of WDTC has 90% overlap \(18 from 20 miRNAs\) with the signature of TCGA. The presence of this miRNA in plasma have been confirmed. Altered expression of miRNAs was tested by qPCR. The study revealed higher expression level of circulating miR\-195\-3p in patients with WDTC in compared to patients with FA, in contrary to results of miRNA expression in tissues."]
