Search for: [Abstract = "erity of skin eruptions two scores \(PASI and USI\) were used. Results\: The first aspirin hypersensivity reaction in AIU patients was preceded by using ASA or non\-steroidal anti\-inflammatory drugs \(NSAIDS\) for a few years and urticaria type skin eruptions. No patients used these drugs during 4 years of observation, half underwent an eliminative diet. The frequency and severity of spontaneous urticarias has decreased as a result. 14 of 22 patients \(63,6 %\) \(AIU\+\+\) produced a positive aspirin oral challenge test once again. The severity of their skin eruptions \(PASImax\) as assessed in 2006 was lower than in 2002. 8 patients \(36,4 %\) \(AIU\+\-\) produced a negative aspirin oral challenge test. The mean LTE4 concentrations in urine did not differ between placebo and ASA in the AIU group and there was no change in LTE4 concentrations after ASA. There was a tendency for increased urinary LTE4 excretion after aspirin challenge in the AIU\+\+ group. LTE4 levels in urine decreased after placebo and aspirin challenge in AIU\+\- group. The dose of aspirin had an effect on LTE4 excretion and there was a correlation between LTE4 excretion and maximal intensity of skin eruptions expressed as PASImax. After aspirin challenge PGD2\-M concentrations in urine rose significantly in the groups\: AIU, AIU\+\+ and AIU\+\-. The mean PGD2\-M concentration in urine after aspirin challenge in 2006 was lower than in 2002"]

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