Search for: [Abstract = "cules able to selectively inhibit a particular GAT protein. The second goal was to design and prepare molecules with simultaneous affinity toward DAT, NERT and SERT. In vitro biological evaluation of newly synthesized molecules was performed in cooperation with Ludwig Maximilian University of Munich. In vivo studies were conducted in the Department of Pharmacodynamics, Faculty of Pharmacy JUMC in Krakow. Propionic acid analogues have been used as a starting point in designing novel GABA uptake inhibitors.Within this thesis, an afficient synthetic procedure towards these compounds was developed. Cross examination of GABA and gamma\-hydroxybutyric acid \(GHB\) derivatives allowed to identify important structural fragments which are possible pharmacophores responsible for the observed activity.As the results six series of serine derivatives along with derivatives of 2,3\-diaminoproponic acid have been optained. The results of in vitro biological activity assays imply moderate inhibition of GABA uptake comparable to other known ligands, but what was gained is clear selectivity toward differnet isoforms of GAT proteins. In vivo examination utilizing a mouse model of neuropathic pain suggests that the obtained, novel compounds show antinociceptive properties. Efforts aimed at the discovery of novel DAT, SERT, NET inhibitors resulted in formulation of new amine building blocks"]

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