Search for: [Abstract = "cid and uvaol, were isolated from this plant material for the first time ever. The isolated terpenoids were then subjected to a series of biological assays. First, using a broad in vitro screening model, their cytotoxic activities were examined against selected cancer cell lines varying in degree of invasiveness and the corresponding normal cells. The highest activity was demonstrated by ursolic acid, and hydroxyl and carboxylic moieties were found to be crucial for maintaining its cytotoxic activity. Moreover, the influence of triterpenes on the cytotoxicity of chloroform extracts prepared from S. intermedia fruits at various developmental stages was also investigated. No correlations were observed between their activities and the contents of triterpenes, which most likely indicates a synergistic effect of several groups of compounds. In the next step, the anti\-inflammatory activities of terpenoids obtained from S. intermedia were assessed. All compounds exerted inhibitory effects on the release of NO, IL\-6 and TNF\-α from RAW264.7 cells stimulated with lipopolysaccharide. Moreover, most compounds displayed anti\-hyaluronidase activity, with ursolic acid and ursolic aldehyde achieving better results than the reference substance – quercetin. Satisfactory results of cytotoxicity studies against prostate cells gave rise to extending the research with the influence of compounds on t"]

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