Search for: [Abstract = "as the number of patients increased, and a subset of molecules \(miR\-191, miR\-126 and miR\-21\-5p\) most likely to be involved in the pathogenesis of the disease were identified and their effect on the transcriptome was experimentally studied using an in vitro model of cells with an endothelial phenotype. The circular part of this transcriptome was also taken into account and, under these model conditions, molecules with the potential to act as biomarkers were selected among the circular RNAs. The study showed that miR\-191 levels differed significantly between the study and control groups. This molecule exerts pleiotropic effects on the transcriptome of endothelial cells, leading to changes in the expression of more than 1,000 genes, and some of the observed changes can be linked to disorders described in the pathogenesis of abdominal aortic aneurysms. In addition to transcripts for protein\-coding genes, numerous circular RNAs are present in endothelial cells. Transfected exogenous microRNAs also influence this part of the transcriptome, supporting the hypothesis of a network of interdependencies between microRNAs, circular RNAs and transcripts of protein\-coding genes."]
