Search for: [Abstract = "alter gene expression at the post\-transcriptional level of messenger RNAs \(mRNAs\). miRNAs are extremely stable and remain intact in tissues, whether fresh, frozen or formalin\-fixed paraffin\-embedded \(FFPE\) 37. This property of miRNAs has been exploited for the development of several commercially available miRNA\-based molecular tests. To date many papers revealed association between malignant neoplasm and altering miRNA expression. In 2006 Weber et al in their study showed miRNA as a potential molecule allowing to discriminate FA and FTC. To date there are many researches emphasising mi RNA as a valuable biomarker, mostly papillary thyroid cancer. Objectives The purpose of this study was twofold\: to characterize the miRNAs signature of the tumors assessed as SFN and to define circulating miRNA pattern to distinguish follicular adenoma from follicular cancer in patients with thyroid nodules verified in FNAB as SFN. Materials and Methods In this study 110 consecutive patients were included. All patients were operated in Department of General Surgery of G. narutowicz Hospital, Third Chair of General Surgery, Jagiellonian University Medical College in Cracow, between 2016 and 2020. The indication for surgery was FNAB result “suspicious for follicular neoplasm”. Inclusion criteria were\: the result of fine needle aspiration biopsy “ suspicious for follicular\/oxyphilic"]
