Search for: [Abstract = "The present experimental investigations were inspired by the necessity of standardizing the procedures and analytical methods employed in hair analysis aiming at a retrospective evaluation of ingestion of various xenobiotics. Thus, in keeping with the principal premises, the main objective of the thesis was development of unique, novel chemico\-toxicological procedures for analyzing the hair content of psychoactive substances in four basic groups of substances of abuse\: opioids \(morphine, 6\-monoacetylmorphine, codeine, methadone and its metabolite \- EDDP\), amphetamines \(amphetamine, methamphetamine, MDA, MDMA, MDEA\), cocaine and its metabolites \(benzoiloecgonine and cocaethylene\) by HPLC\-APCI\-MS\-MS and cannabinoids \(∆9\-THC and cannabinol\) by GC\-EI\-MS\-MS , followed by verification of the thus worked out procedures in medico\-legal practice through opinionating in selected groups of cases\: participants in methadone substitution therapy \(abstinence control\), teenage abusers of psychoactive substances \(medical diagnosis\) and patients deceased due to fatal psychoactive substance poisoning \(cause of death determination\)."]

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