Search for: [Abstract = "The main goal of the project was to comprehensively assess the phenotype of fibrin clots and identify new factors responsible for the decreased efficiency of fibrinolysis in patients with aortic stenosis \(AS\). In article 1, the comparison of three assays that are now commonly used to evaluate fibrinolytic capacity in citrate plasma was performed. The impact of sociodemographic and laboratory factors on the fibrinolytic efficiency was assessed with the methods. Additionally, the strongest determinants for prolonged lysis times were determined. The study provided evidence for significant differences among fibrinolysis assays in terms of demographic and laboratory determinants. In article 2, the impact of elevated oxidative stress was evaluated regarding the AS progression and fibrinolytic disorders. For this purpose, levels of global oxidation blood markers, as well as fibrinolytic efficiency, were determined. It has been shown that higher levels of oxidative stress, expressed by oxidation markers, was associated with reduced fibrinolytic efficiency and disease severity in patients with isolated AS. Patients with the highest levels of oxidation stress were characterized by the fibrin composed of thinner fibrin fibers that formed a denser and less lysable clots as compared with the remaining patients. Moreover, oxidation markers have been significant determinants of decreased ef"]

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