Search for: [Abstract = "The aim of this PhD thesis was to determine the activity of nine arylpiperazine derivatives of phenytoin \(LL\-1, LL\-2, LL\-3, LL\-4, LL\-9, BS\-8, MN\-1, MN\-6 and TN\-11\) toward α1\-adrenoceptor subtypes in terms of potential circulatory and urological activity with respect to the reference compounds, and also to investigate the relationship between the structure and affinity for α1\-adrenoceptors and pharmacological activity of tested compounds. The results of pharmacological in vivo and in vitro studies showed significant α1\-adrenolythic and circulatory activity of tested compounds. None of the tested compounds showed selective α1A\- and\/or α1D\-adrenolytic activity, and therefore none of them have selective affinity for urogenital tract, which could be used in the treatment of benign prostatic hyperplasia.These results showed also a high correlation between the affinity for α1\-adrenoceptor of tested compounds and their hypotensive and antiarrhythmic activity, wherein, according to the structure \- activity analysis, the highest affinity for α1\-adrenoceptors and also the highest α1\-adrenolythic activity showed compounds with 2\-alkyloxyphenylpiperazine and 3\-alkyloxyphenylpiperazine moiety in their structure."]

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