Search for: [Abstract = "Swedish whitebeam \(Sorbus intermedia \(Erh.\) Pers., Rosaceae\) is an endemic of the Baltic Region, which, due to its decorative value and frequent use in public greenery, has spread throughout Europe. Chemotaxonomic data clearly indicated that S.intermedia may serve as a potential source of triterpenes. Therefore, the main objective of the present dissertation was phytochemical analysis of the S. intermedia fruits aiming at indication of a new and easily available source of triterpenes with a defined biological activities. The basic research tasks included the analysis of the dynamics of accumulation of selected triterpenes during the growing season with the parallel isolation of predominant compounds from this plant material. In turn, the biological investigations concerned the evaluation of\: 1\) cytotoxic activity, 2\) anti\-inflammatory activity, i.e. protective effects against heat\-induced bovine albumin denaturation, inhibition of release of pro\-inflammatory mediators from activated macrophages, and anti\-hyaluronidase activity, 3\) anti\-androgenic and anti\-proliferative activities in an cellular model of benign prostatic hyperplasia. The studies indicated ursolic acid as the predominant triterpene present in the S. intermedia fruits. Moreover, ββ\-sitosterol and five ursane\-type triterpenes, i.e. ursolic acid, 3ββ\-O\-acetoxy\-ursolic acid, ursolic aldehyde, 3ββ\-O\-acetoxy\-pomolic a"]

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