Search for: [Abstract = "Introduction Thyroid nodules occur in 65% of population. Most of them are benign lesions. Recent large retrospective studies conducted at a high\-volume centers revealed TC in 3%–15% of biopsies. Thyroid cancer \(TC\) accounts for more than 95% of endocrine cancers. Over the last three decades TC has become one of the most rapidly increasing cancer in the USA. Fine needle aspiration biopsy \(FNAB\) comprises basic method in preoperative diagnostic work\-up. FNAB is charakcteryzed by high level of accuracy and enables to preliminary assessment of the lesions as benign or malignant. The results are presented according to the Bethesda system which categorizes into six groups. In the doctoral the analysis of patients with FNAB result Bethesda tier IV \- suspicious for follicular neoplasm \(SFN\) has been performed. The malignancy rate varies between 8,2 – 19%. To date, there are no diagnostic tools allowing to exclude malignancy and indeterminate cytopathology often requires diagnostic surgery for definitive. There have been several studies appraising the potential of miRNAs as diagnostic markers for thyroid cancer. miRNAs are endogenous, single\-stranded, tiny, highly conserved, noncoding molecules with lengths ranging from 18 to 25 nucleotides RNAs. miRNAs are encompassed in many biological and pathological processes as proliferation, differentiation and apoptosis. miRNAs"]
