Search for: [Abstract = "Introduction Crohn's disease \(CD\), one of the inflammatory bowel diseases \(IBD\), is a transmural, usually granulomatous inflammation that can affect any part of the gastrointestinal tract. The main mechanism of intestinal inflammation in CD is the imbalance between Th1 and Th17 effector lymphocytes acting through the secretion of IFN\-γ, TNF\-α, pro\-inflammatory interleukins such as IL\-6, IL\-12, IL\-17, IL\-22 and other mediators, and regulatory T cells \(Treg\) secreting IL\-10, IL\-35 and TGF\-β. Although the role of many cytokines in the pathogenesis and clinical course of CD is widely researched and well explained, they are not used for diagnostic purposes. Many articles have been published on the cytokine networks and serum level profiles in IBD, but data on their diagnostic characteristics are scarce. The aim of the study was to compare the serum concentrations of inflammatory markers \/ mediators, including CRP, IFN\-γ, IL\-6, IL\-10, IL\-12, IL\-17A, IL\-19 and IL\-23, and the results of their multiplication between patients with CD, its active and inactive form and a control group and the assessment of their diagnostic characteristics in the diagnosis \/ exclusion of CD and its active phase. Methods The study group consisted of 49 patients with CD assigned to the active \(33 patients\) and inactive \(16 patients\) disease subgroups based on CDAI, and 31 healthy controls. Se"]

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