Szukana fraza: [Abstrakt = "Introduction\: Pursuant to identification of various phenotypes of asthma, attempts are made aiming at developing an individualized biological therapy. The key role played by immunoglobulin E \(IgE\) in an allergic reaction has culminated in the development of omalizumab – a monoclonal antibody against the IgE particle. The studies completed to date have demonstrated the clinical effectiveness of omalizumab therapy, yet the effect of such treatment on airway remodeling has not been fully investigated. Objective\: The objective of the present study was the assessment of the effect of biological therapy on airway remodeling, as well as evaluation of the effectiveness of omalizumab treatment in patients with severe allergic asthma. Material and methods\: The investigation included 31 patients previously qualified to the omalizumab treatment program by the Biological Treatment in Severe Allergic Asthma Coordinating Team appointed by the President of the National Health Fund. The study was prospective and observational in character\; no control group was used. Thirteen patients were additionally subjected to bronchofiberoscopy with broncho\-alveolar lavage \(BAL\) and collection of specimens from the bronchial mucosa. Results and conclusions\: The present study demonstrated that biological treatment with omalizumab resulted in improving asthma control and quality"]

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