Search for: [Abstract = "Genetics and environmental factors play a role in the pathogenesis of the complex disease, type 2 diabetes mellitus. Two major pathophysiological defects coexist m this disease\: impairment of insulin secretion by β\-cells and decreased insulin sensitivity in peripheral tissues. The aim of the study was to examine whether two polymorphisms\: the \-308 G\/ A substitution in the promoter region of TNF\-α. gene and the K121Q amino acid variant of the PC\- 1 gene influence insulin resistance in individuals with positive family history of type 2 diabetes mellitus. In order to describe a role of these polymorphisms in Type 2 diabetes mellitus development in a Polish population a case – control study was performed. 120 healthy subjects with normal glucose tolerance were enrolled. Insulin resistance measures were taken \(indirect, verified by the metabolic clamp\). Homozygous and heterozygous carriers of the A allele in position \-308 of the TNF\-α. gene promoter showed higher plasma insulin levels at 120 min OGTT versus GG carriers \(5,88\; SD 6,5 wobec 3,36\; SD 2,4\; p = 0,04\). In addition, carriers of the Q allele at residue 121 of the PC\-1 gene showed higher plasma glucose levels at 120 min OGTT compared to the KK subjects \(5,03\; SD 1,25 wobec 4,68\; SD 1,31\; p = 0,04\). In case \- control study no difference in allele distribution was found. Our study suggests that both examined polymorphisms infl"]

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