Search for: [Abstract = "Curcumin is a biologically active component of the root of Curcuma longa, used for many centuries as a culinary spice in the Far East. Its use in traditional medicine in the treatment of various diseases, such as diabetes, gastrointestinal diseases, rheumatic diseases, atherosclerosis, infections and cancer, also stretches back many centuries. In modern medicine there is increasing interest in the multidirectional therapeutic effects of curcumin which exhibits antioxidant and anti\-inflammatory activity. One key feature of curcumin is its excellent tolerability, low toxicity and a lack of side effects after its administration\; however, curcumin's bioavailability is low, and therefore it exhibits its effects mainly within the gastrointestinal tract.Gastroprotection means the ability of certain mechanisms, including in particular the prostaglandins, to prevent the formation of acute injury to the mucosa, whereas this effect occurs regardless of their inhibitory effect on the secretion of gastric acid.The purpose of the study was to examine whether curcumin exhibits gastroprotective effects in experimental acute ethanol\- and stress\-induced injuries of the gastric mucosa and which factors and mechanisms mediate this effect.In the first stage of the study an evaluation was made of the effect of intragastrically applied curcumin on basal and histamine\- or pentagastrin\-stimulated gastr"]

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