Search for: [Abstract = "Atrial fibrillation increases the risk of stroke five\-fold. The most common site of intracardiac thrombus formation in patients with AF is the left atrial appendage \(LAA\), where more than 90% of embolic thrombi are found. Percutaneous LAA closure procedure became an alternative method for stroke prevention in patients with non‐valvular atrial fibrillation intolerant to long term oral anticoagulation therapy. Percutaneous LAAC procedures may be divided into endocardial and epicardial approaches. Previous studies show that LAA closure is associated with good short\- and midterm results. Unfortunately, there are no recent analyses of the causes of death and clinical outcomes of high\-risk patients undergoing LAA closure. Aim The primary aim of this study was to assess the effectiveness and safety of the LAA closure in patients with high risk of thromboembolism and to evaluate survival free of any serious adverse events and of any‑cause death in long term observation. The secondary objective was to analyze the results of treatment with a novel occluder. In addition, a comparison was made between endocardial LAA occlusion \(LAAO\) and epicardial LAA closure \(LAAC\). Materials and methods A retrospective observational study was performed on 223 consecutive patients with nonvalvular AF, who underwent LAA closure with the LAmbre, Amplatzer or Lariat system in two centers\: Department of"]
