Search for: [Abstract = "Anthracyclines are a group of oncological drugs commonly used in a therapy, and their wide spectrum of activity and high efficiency make them constituents of many chemotherapy regimens. Unfortunately, the activity of anthracyclines is often reduced due to the resistance of cancer cells, which limits the effectiveness and therapeutic potentia\! of these drugs. Over the years, many mechanisms of drug resistance of can cer cells have been discovered. In the case of anthracyclines, a special role in resistance is attributed to transmembrane transporters, mainly from the ABC family, especially ABCBl, which, through the active efflux of drugs across the cell membrane, reduce intracellular concentrations of the drug, reducing their cytotoxic and cytostatic activity. In recent years, there has been increasing concern about the role of drug\-metabolizing enzymes in the course of resistance. In the case of anthracyclines, these are cytosolic enzymes from the group of short\-chain dehydrogenases\/reductases \- carbonyl reductases and aldo\-keto reductases. These enzymes catalyse the reduction reaction of the carbonvl group of the side chain"]

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