Search for: [Abstract = "An aortic aneurysm is a localized, abnormal dilatation of the lumen of the aorta. The affected vessel has been shown to have histological abnormalities and a wall susceptible to dissection or rupture. Risk factors include smoking, hypertension, male sex and advanced age, but the unclear pathogenesis of the disease has prevented the introduction of effective conservative treatment. A positive family history is also associated with a significantly higher risk of the disease, but a consistent inheritance model is still not in place. This suggests the involvement of epigenetic processes in its pathogenesis, which in turn allows attempts to use molecules that modify genetic expression as potential biomarkers to diagnose or monitor disease progression. Indeed, the lack of specific biomarkers makes it difficult to choose the right time for elective surgery. The present study therefore sought to evaluate noncoding RNAs in the context of abdominal aortic aneurysms, both in terms of their association with disease pathogenesis and their potential use as biomarkers. The work was preceded by a preliminary study in which the profile of microRNAs in the serum of patients with abdominal aortic aneurysms was determined in comparison to controls. A pool of 10 molecules was selected that best differentiated the study group from the control group. The levels of the selected molecules were measured"]
